詹妮弗·邦纳

Associate Professor of Biology

地址:
生物系 - CIS 210C
火博体育大学
萨拉托加泉，纽约州12866

电话:
(518) 580-5089

传真:
(518) 580-5071

个人网站:
http://jbonner.weebly.com/

电子邮件:
jbonner@psychomotricite-la-seyne.com

Education and Professional Training:

University of New Hampshire, BA, Microbiology
University of British Columbia, PhD, Neuroscience
University of Utah, postdoctoral fellow

课程:

Biology 106 Biological Sciences II
247细胞生物学
【火博体育官网】神经发育
Biology 342 Frontiers in Molecular Neuroscience
Biology 385 Methods in Molecular Biology and Genetics, Integrative Biology, and Ecology, 进化与行为
Neuroscience 101 Introduction to Neuroscience
Neuroscience 277 Integrative Seminar in Neuroscience

主要研究方向:

The long-term goal of my research is to determine the genes that control 神经系统 连接. I am using zebrafish as a model system to address this question, and focusing on the spinal cord due to its relative simple structure and homology to higher 脊椎动物包括人类. Several evolutionarily conserved classes of neurons are found in the zebrafish spinal cord, including commissural neurons, sensory neurons, 和运动. Commissural neurons connect the two halves of the 神经系统 and develop by responding to both attractive and repulsive signals, which allow them to cross the middle of the animal, called the midline. Sensory neurons project anterior and posterior in the spinal cord, while also projecting to the skin, elaborating extensive 乔木. Finally, motoneuron cell bodies, positioned in the ventral spinal cord, project out of the spinal cord to the 肌肉组织. I am interested in the guidance cues that direct the pathfinding of these neuronal subtypes. To do this, I am using genetics, gene knockdown technology, and cell biology to study the mechanisms of neuron pathfinding and exploring potential novel roles for canonical guidance cues.

Confocal time series of GFP labeled spinal cord neurons as they project posteriorly 在斑马鱼胚胎中. Two spinal tracts enter the field from the right (anterior) 脊髓的一侧. Large GFP labeled ectodermal cells can also be seen migrating 整个胚胎. (点击图片观看视频)

Time-lapse confocal movie of GFP-labeled zebrafish motoneurons innervating the surrounding 肌肉组织. (点击图片观看视频)

同行评审出版物:

贝克A，瓦特，R. 邦纳J. (2014) Mounting of zebrafish embryos for optimal microscopy. 杂志 Visual Experimentation (84):e50703.

罗斯, 邦纳J. (2012) Activation of Wnt signaling using Lithium Chloride: An Inquiry based Model of Undergraduate Laboratory Exercises. 斑马鱼，准备好了.

斯普纳点, 邦纳J, Maricq AV, Benian GM, Norman KR. (2012) Large isoforms of UNC-89-obscurin are required for muscle cell architecture and calcium release in Caenorhabditis elegans. 公共科学图书馆7 (7):e40182

邦纳J, Letko米Nikolaus OB; 克鲁格L, 库珀一, 查德威克B, 康克林P, Lim A, Chien CB, Dorsky RI. (2012) Midline crossing is not required for subsequent pathfinding decisions in commissural neurons. 神经发育7(1):18

格里布尔SL，金HS， 邦纳J王晓明，王晓明. (2009) Tcf3 inhibits spinal cord neurogenesis by regulating sox4a 表达式. 发展136 (5):781 - 9.

邦纳J, Gribble SL, Veien ESNikolaus OB; Weidinger G, Dorsky RI. (2008)扩散 and patterning are mediated independently in the dorsal spinal cord downstream of 典型Wnt信号. Development Biology 313(1):398-407.

刘易斯杰, 邦纳J, Modrell M, Ragland JW, Moon RT, Dorsky RI, and Raible DW. (2004)重申Wnt signaling during zebrafish neural crest development. 发展131 (6),1299 - 1308.

邦纳J， Gerrow KA和O'Connor TP. (2003) The Ti1 pioneer pathway: An 在活的有机体内 model for neuronal outgrowth and guidance. Methods in Cell Biology 71:171-193.

邦纳J，奥尔德VJ和奥康纳TP. (2002) Migrating mesoderm establish a uniform distribution of laminin in the developing grasshopper embryo. Developmental Biology 249(1):57-73.

邦纳J 和奥康纳TP. (2001) The permissive cue laminin is essential for growth cone turning 在活的有机体内. 杂志 Neuroscience 21(24):9782-91.

邦纳J 和奥康纳TP. (2000) Semaphorin function in the developing invertebrate peripheral 神经系统. Biochemistry and Cell Biology 78(5): 603-611.

Honer WG, Falkai P, Young C, Wang T, Xie J, 邦纳J , Hu L, Boulianne GL, Lu Z, Trimble WS. (1997) Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia. 神经科学学报[j] (1): 99-110.

最近的实验室学生